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Many different immunosuppressive medications have been linked to HBV reactivation, with B-cell depletion agents posing some of the highest risk for reactivation.[8] When multiple drugs are given concurrently or in quick succession, it is challenging to discern the precise risk posed by specific drugs due to a lack of systematically collected data.[3] Risk Categories for HBV Reactivation Based on studies and reports in the literature, the American Association for the Study of Liver Diseases (AASLD) and the American Gastroenterological Association (AGA) have categorized HBV serologic status and immunosuppressive medications by their level of risk for HBV reactivation